Biotech comes to its 'antisenses' after hard-won drug approval

After Hard Drives — What Comes Next ?

There are numerous emerging nonvolatile memory technologies, which have been proposed as being capable of replacing hard disk drives (HDDs). In this paper, the prospects for these alternative technologies to displace HDDs in 2020 are analyzed. In order to compare technologies, projections were made of storage density and performance in year 2020 for both hard disks and the alternative technolog...

Hard Won and Easily Lost

This article reviews evidence that manhood is seen as a precarious social status that is both difficult to achieve and tenuously held. Compared with womanhood, which is typically viewed as resulting from a natural, permanent, and biological developmental transition, manhood must be earned and maintained through publicly verifiable actions. Because of this, men experience more anxiety over their...

Drug approval and drug effectiveness.

Data on the efficacy and safety of psychiatric medicines should form the foundation of evidence-based treatment practices. The US Food and Drug Administration (FDA) reviews such data in determining whether to approve new treatments, and the published literature serves as a repository for evidence on treatment benefits and harms. We describe the FDA review of clinical trials, examining the under...

Climate science, character, and the "hard-won" consensus.

What makes a consensus among scientists credible and convincing? This paper introduces the notion of a "hard-won" consensus and uses examples from recent debates over climate change science to show that this heuristic standard for evaluating the quality of a consensus is widely shared. The extent to which a consensus is "hard won" can be understood to depend on the personal qualities of the par...

The 'axe man' departs, offering hard-won lessons.